Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Natural killer cells and autoimmunity.

Anthony R French1, Wayne M Yokoyama

  • 1Howard Hughes Medical Institute, Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. yokoyama@im.wustl.edu

Arthritis Research & Therapy
|February 26, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial Expression of Concern: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

Nature immunology·2026
Same author

Inducible T-bet deletion reveals tissue-specific requirements in NKp46+ ILC immunobiology and response to murine cytomegalovirus.

Nature communications·2026
Same author

CD8<sup>+</sup> T cells are primed by cDC1 and exacerbate tau-mediated neurodegeneration.

bioRxiv : the preprint server for biology·2026
Same author

TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy.

bioRxiv : the preprint server for biology·2025
Same author

Eomesodermin defines uterine NK cells crucial for pregnancy success in mice.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.

eLife·2025
Same journal

Differential gene expression of retrotransposons (LTR and non-LTR) in peripheral blood leukocytes of people with gout.

Arthritis research & therapy·2026
Same journal

Alterations in systemic and skeletal muscle myostatin regulation are most prominent at disease onset and associate with muscle-related outcomes in idiopathic inflammatory myopathies.

Arthritis research & therapy·2026
Same journal

Plasma proteome differences between giant cell arteritis and polymyalgia rheumatica: a pilot study.

Arthritis research & therapy·2026
Same journal

Elucidating the mechanism of taurine in alleviating osteoarthritis progression based on bioinformatics, machine learning algorithm, and experimental validation.

Arthritis research & therapy·2026
Same journal

Discovery of biomarkers for primary Sj ögren's syndrome based on multi-omics data, construction of diagnostic models, and clinical correlation analysis.

Arthritis research & therapy·2026
Same journal

Identification of distinct subgroups in Chinese patients with Behçet's syndrome via cluster analysis of immune cells and clinical features.

Arthritis research & therapy·2026
See all related articles

Natural killer (NK) cells, part of the innate immune system, may regulate autoimmune diseases. Recent research explores how NK cells influence T and B cell activity in autoimmunity.

Area of Science:

  • Immunology
  • Autoimmunity
  • Innate Immune System

Background:

  • Autoimmune diseases involve aberrant T and B cell activation, causing tissue damage.
  • The innate immune system, including natural killer (NK) cells, is increasingly recognized for its role in autoimmunity.
  • NK cells may either promote or suppress autoimmune conditions.

Purpose of the Study:

  • To review recent research on the immunoregulatory functions of NK cells.
  • To elucidate the role of NK cells in modulating T and B cell-mediated autoimmunity.

Main Methods:

  • Literature review of current studies on NK cells and autoimmunity.
  • Analysis of research investigating NK cell interactions with T and B cells in autoimmune contexts.

Related Experiment Videos

Main Results:

  • Evidence suggests NK cells possess immunoregulatory capabilities in autoimmune settings.
  • NK cells can influence the activation and function of T and B lymphocytes.
  • Specific NK cell subsets and their mechanisms in autoimmunity are being identified.

Conclusions:

  • NK cells represent a promising target for therapeutic strategies in autoimmune diseases.
  • Further research is needed to fully understand NK cell heterogeneity and function in autoimmunity.