Related Experiment Videos
Acquired hyperoxaluria and haematuria in children
A Voghenzi1, T M Bezzi, P Lusardi
1Paediatric Institute, Ferrara University, Italy.
Insights
Children who underwent extensive ileal resection can develop acquired hyperoxaluria, leading to non-glomerular haematuria. This suggests hyperoxaluria may cause haematuria through a mechanism similar to hypercalciuria.
Area of Science:
- Nephrology
- Pediatric Gastroenterology
- Urology
Background:
- Intestinal disorders, particularly following extensive ileal resection, are associated with acquired hyperoxaluria in children.
- Gross haematuria of non-glomerular origin, without evidence of kidney stones or nephrocalcinosis, is a concerning clinical presentation in pediatric patients.
Observation:
- Two pediatric cases with extensive ileal resection presented with significant gross haematuria.
- These children did not exhibit urolithiasis or nephrocalcinosis, ruling out common causes of haematuria.
Findings:
- Both patients demonstrated elevated urinary oxalate levels, confirming acquired hyperoxaluria.
- The presence of hyperoxaluria in these cases suggests a potential link to the observed haematuria.
Implications:
- Acquired hyperoxaluria secondary to ileal resection may be a novel cause of non-glomerular haematuria in children.
- This finding warrants further investigation into the pathogenetic mechanisms linking hyperoxaluria to haematuria, potentially mirroring pathways seen with hypercalciuria and hyperuricosuria.
Abstract:
Two children with extensive ileal resection are reported. They developed gross haematuria of "non-glomerular origin", without stones or nephrocalcinosis. Previous reports indicate that acquired hyperoxaluria is common in children with a variety of intestinal disorders. Our patients had hyperoxaluria. We think that hyperoxaluria may be the cause of haematuria through a pathogenetic mechanism similar to the one ascribed to haematuria secondary to hypercalciuria and hyperuricosuria.