Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epidermal lipids.

P W Wertz1

  • 1Dows Institute for Dental Research, University of Iowa, Iowa City 52242.

Seminars in Dermatology
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Epidermal lipids are crucial for skin barrier function and cell regulation. Understanding their composition, including ceramides and cholesterol, is key to skin health and differentiation processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Naturally occurring ω-Hydroxyacids.

International journal of cosmetic science·2017
Same author

Spectrophotometric Evaluation of Potassium Nitrate Penetration Into the Pulp Cavity.

Operative dentistry·2015
Same author

Current understanding of skin biology pertinent to skin penetration: skin biochemistry.

Skin pharmacology and physiology·2013
Same author

Organization, barrier function and antimicrobial lipids of the oral mucosa.

International journal of cosmetic science·2013
Same author

Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage.

Skin pharmacology and physiology·2012
Same author

The relationship of hydrogen peroxide exposure protocol to bleaching efficacy.

Operative dentistry·2012
Same journal

Genital herpes simplex virus and its treatment: focus on famciclovir.

Seminars in dermatology·1996
Same journal

Efficacy of famciclovir in the treatment of herpes zoster.

Seminars in dermatology·1996
Same journal

The pharmacological profile of famciclovir.

Seminars in dermatology·1996
Same journal

Epidemiology and management of postherpetic neuralgia.

Seminars in dermatology·1996
Same journal

Varicella-zoster virus: overview and clinical manifestations.

Seminars in dermatology·1996
Same journal

Advances in the management of herpesvirus infections. Introduction.

Seminars in dermatology·1996
See all related articles

Area of Science:

  • Dermatology
  • Biochemistry
  • Cell Biology

Background:

  • Epidermal lipids are vital for skin structure, cell growth, differentiation, cohesion, desquamation, and barrier function.
  • Understanding epidermal lipid composition is essential for elucidating these critical roles.
  • Key lipids include phospholipids, ceramides, cholesterol, and fatty acids.

Purpose of the Study:

  • To detail the structures and compositions of epidermal lipids.
  • To understand the functional significance of various epidermal lipid classes.
  • To explore the role of lipids in epidermal differentiation and barrier formation.

Main Methods:

  • Analysis of epidermal lipid composition.
  • Investigation of lipid structures within keratinocytes and the stratum corneum.

Related Experiment Videos

  • Examination of lipid involvement in cell differentiation and barrier mechanisms.

    • Main Results:

    • Phospholipids are key in plasma membranes and signaling within keratinocytes.
    • Monosexosylceramides transform into ceramides in the stratum corneum, contributing to barrier integrity.
    • Stratum corneum lipids (ceramides, cholesterol, fatty acids) prevent water loss and environmental agent penetration.

    Conclusions:

    • Epidermal lipids, particularly ceramides, are essential for the skin's permeability barrier and overall health.
    • Lipid composition directly influences epidermal differentiation and barrier function.
    • Sphingosine from ceramides may regulate epidermal differentiation through feedback mechanisms.