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Related Experiment Videos

Physical methods for studying stratum corneum lipids.

R O Potts1, M L Francoeur

  • 1Cygnus Therapeutic Systems, Redwood City, CA 94063.

Seminars in Dermatology
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

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Altering stratum corneum lipid packing increases skin permeability, which can be predicted by physical properties. This research offers insights into skin transport mechanisms and selecting agents to modify skin permeability.

Area of Science:

  • Biophysics
  • Dermatology
  • Materials Science

Background:

  • The stratum corneum lipids are crucial for skin barrier function, regulating water loss and drug permeation.
  • Understanding the biophysical properties of these lipids is key to controlling skin permeability.

Purpose of the Study:

  • To investigate the relationship between stratum corneum lipid properties and skin permeability.
  • To explore methods for predicting and altering skin permeability.

Main Methods:

  • Utilized infrared spectroscopy and differential scanning calorimetry to analyze stratum corneum lipid structure.
  • Evaluated in vitro and in vivo methods for assessing lipid physical properties.

Main Results:

  • Demonstrated that altered stratum corneum lipid packing directly correlates with increased skin permeability.

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  • Showed that the degree of permeability increase can be accurately predicted from measured physical properties.

    • Conclusions:

    • Changes in stratum corneum lipid organization significantly impact skin barrier function.
    • These findings provide a framework for understanding skin transport and developing agents that modulate skin permeability.