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Related Experiment Videos

Model studies of epidermal permeability.

Y H Kim1, A H Ghanem, W I Higuchi

  • 1Department of Pharmaceutics, College of Pharmacy, University of Utah, Salt Lake City 84112.

Seminars in Dermatology
|June 1, 1992
PubMed
Summary
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This study presents a physical model for skin transport, predicting molecular behavior based on polarity. The model accurately describes permeant transport and enhancement mechanisms, aiding in drug delivery research.

Area of Science:

  • Dermal transport and biophysics
  • Pharmacokinetics and drug delivery
  • Computational modeling in biology

Background:

  • Understanding skin's barrier function is crucial for transdermal drug delivery.
  • Existing models often simplify the complex multi-layered structure of the skin.
  • Predicting molecular permeation requires accounting for different pathways within the stratum corneum.

Purpose of the Study:

  • To develop and validate an in vitro physical model for predicting molecular and ionic transport across the skin.
  • To elucidate the mechanisms of skin transport enhancement induced by short-chain alkanols.
  • To correlate model predictions with experimental permeability data.

Main Methods:

  • Development of a two-layer (stratum corneum, epidermis-dermis) in vitro physical model.

Related Experiment Videos

  • Modeling the stratum corneum with parallel lipoidal and pore pathways.
  • Comparison of model predictions with experimental permeability coefficients using hairless mouse skin.
  • Application of the model to study alkanol-induced transport enhancement.

    • Main Results:

    • The model accurately predicts three transport regimes based on permeant lipophilicity: lipophilic, polar, and intermediate polarity.
    • Extremely lipophilic molecules are limited by the epidermis-dermis.
    • Extremely polar permeants are limited by the stratum corneum's pore pathway.
    • Intermediate polarity permeants utilize the lipoidal pathway, with permeability dependent on lipophilicity.
    • Alkanols enhance transport by disrupting lipid bilayers at low concentrations, with pore pathways dominating at higher concentrations.

    Conclusions:

    • The developed physical model provides a robust framework for describing and predicting skin transport.
    • The model successfully explains the differential transport of molecules based on their physicochemical properties.
    • The findings offer insights into optimizing transdermal drug delivery systems and understanding penetration enhancers.