Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Occult hepatitis B virus infection.

Jean-Pierre Allain1

  • 1Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge Blood Centre, Long Road, Cambridge CR2 2PT, UK. jpa1000@cam.ac.uk

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|February 26, 2004
PubMed
Summary

Occult Hepatitis B infection (OBI) involves detecting HBV DNA without HBsAg, posing transfusion risks. Screening methods like anti-HBc and sensitive HBV DNA tests are crucial for blood safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infectivity of Hepatitis B Virus Surface Antigen-Positive Plasma With Undetectable HBV-DNA: Can HBsAg Screening Be Discontinued in Egyptian Blood Donors?

Journal of viral hepatitis·2024
Same author

Early Phase of Specific Cellular Immune Status Associates with HCV Infection Outcomes in Marmosets.

Viruses·2023
Same author

Occult Hepatitis B Virus Infection and Liver Fibrosis in Chinese Patients.

The Journal of infectious diseases·2023
Same author

Anti-HBc-nonreactive occult hepatitis B infections with HBV genotypes B and C in vaccinated immunocompetent adults.

Journal of viral hepatitis·2022
Same author

Hepatitis B Virus-Specific Cellular Immunity Contributes to the Outcome of Occult Hepatitis B Virus Infection.

Frontiers in microbiology·2022
Same author

Hepatitis B Virus Chronic Infection in Blood Donors from Asian and African High or Medium Prevalence Areas: Comparison According to Sex.

Viruses·2022

Area of Science:

  • Hepatology
  • Virology
  • Transfusion Medicine

Background:

  • Occult Hepatitis B infection (OBI) is defined by the presence of HBV DNA without detectable HBsAg, often with HBV antibodies.
  • OBI is found in various conditions including hepatocellular carcinoma, chronic hepatitis B, and resolved infections.
  • The detection frequency of OBI relies on assay sensitivity and HBV prevalence.

Purpose of the Study:

  • To explore the origins and implications of occult Hepatitis B virus (HBV) infection in blood donors.
  • To assess the transmissibility of occult HBV through blood transfusion.
  • To evaluate the effectiveness of current screening methods for occult HBV.

Main Methods:

  • Review of existing literature on occult HBV infection.
  • Analysis of HBV DNA and serological marker detection methods (HBsAg, anti-HBs, anti-HBc).

Related Experiment Videos

  • Evaluation of transfusion transmission risks in different recipient populations.

    • Main Results:

    • Occult HBV can originate from recovered infections, low-level replication, or chronic carriage, often with anti-HBc only.
    • Viral loads in OBI are typically low (<10(4) IU/ml), challenging pooled nucleic acid testing (NAT).
    • Donations with anti-HBc and HBV DNA can be infectious, particularly for immunosuppressed recipients.

    Conclusions:

    • Anti-HBc screening detects most OBI but is not exhaustive.
    • Highly sensitive individual donation NAT is necessary to eliminate infectious units.
    • Understanding OBI is critical for ensuring blood transfusion safety.