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A peptidyl transferase ribozyme capable of combinatorial peptide synthesis
Zhiyong Cui1, Lele Sun, Biliang Zhang
1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Bioorganic & Medicinal Chemistry
|February 26, 2004
Abstract:
The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.