Related Experiment Videos
Hypersensitivity reactions to cisplatin and carboplatin--a report on six cases
M P Saunders1, C P Denton, M E O'Brien
1Department of Medicine, Royal Marsden Hospital, London, U.K.
Abstract:
Anaphylactic reactions to platinum compounds are well recognised, but uncommon. These vary from true type I reactions to direct histamine release due to nonimmunological mechanisms. We present 6 cases to illustrate this--5 due to cisplatin and a report of this occurring with carboplatin--with a near fatal outcome in 3 of the cases.