Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gender differences in lipoprotein lipase activity after acute exercise.

Leigh Perreault1, Jennifer M Lavely, John M Kittelson

  • 1Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. leigh.perreault@uchsc.edu

Obesity Research
|February 26, 2004
PubMed
Summary

Men show increased lipoprotein lipase (LPL) activity after exercise, unlike women. This study investigated gender differences in LPL activity following exercise and insulin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mediators and moderators of successful population-level weight management in primary care: results from the PATHWEIGH cluster-randomized pragmatic trial.

International journal of obesity (2005)·2026
Same author

Defining prediabetes remission as a distinct prevention endpoint.

The lancet. Diabetes & endocrinology·2025
Same author

Implementation and effectiveness of a care process to prioritize weight management in primary care: a stepped-wedge cluster-randomized trial.

Nature medicine·2025
Same author

Artificial Intelligence and Diabetes Prevention.

JAMA·2025
Same author

Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition.

Diabetes·2025
Same author

Primary care patient and practice member perspectives on weight loss medications: challenges and opportunities.

Frontiers in medicine·2025

Area of Science:

  • Exercise physiology
  • Metabolic research
  • Gender differences in physiology

Background:

  • Lipoprotein lipase (LPL) activity is crucial for lipid metabolism and may predict obesity risk.
  • While exercise and insulin modulate LPL in men, their effects in women are less understood.
  • Understanding LPL regulation is vital for metabolic health strategies.

Purpose of the Study:

  • To investigate gender-specific differences in lipoprotein lipase (LPL) activity in skeletal muscle and adipose tissue.
  • To determine the impact of a single bout of exercise and subsequent hyperinsulinemic/euglycemic clamp on LPL activity in men and women.
  • To clarify the role of exercise and insulin as modulators of LPL activity across genders.

Main Methods:

  • Healthy lean men and women (n=10 each) underwent a single bout of exercise or a rest day, followed by a hyperinsulinemic/euglycemic clamp.

Related Experiment Videos

  • Skeletal muscle and adipose tissue biopsies were collected pre- and post-clamp to measure LPL activity.
  • A comparative analysis was performed between exercise and rest conditions, and between genders.

    • Main Results:

    • No significant baseline differences in muscle or adipose tissue LPL activity were observed between men and women.
    • A significant gender-by-day interaction indicated differing responses to exercise: men showed increased LPL activity in both muscle and adipose tissue.
    • Women did not exhibit increased LPL activity in muscle post-exercise, and showed a trend towards decreased activity in adipose tissue.

    Conclusions:

    • Post-exercise, men demonstrated a significant increase in both muscle and adipose tissue LPL activity within 3-4 hours.
    • In contrast, LPL activity remained unchanged in women during the same post-exercise period.
    • The hyperinsulinemic/euglycemic clamp did not independently affect tissue LPL activity in either gender after rest or exercise.