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Published on: February 12, 2015
Whole deletion of CYP2A6 gene (CYP2A6AST;4C) and smoking behavior
Kazuhiko Iwahashi1, Chikako Waga, Takahiro Takimoto
1Department of Neurophysiology, Graduate School of Azabu University, Sagamihara, Japan. iwahashi@azabu-u.ac.jp
Abstract:
The relationship between nicotine metabolism of CYP2A6 and the smoking behavior in a Japanese population was investigated. The CYP2A6 genotypes were determined by the PCR method. There was a significant difference in the frequency of the CYP2A6AST;4C allele, which is a whole deleted allele for the human CYP2A6 gene, between smokers and nonsmokers. The frequency of the CYP2A6AST;4C allele was higher in nonsmokers than in smokers, whereas the frequency of CYP2A6AST;1A/AST;1B heterozygotes with a higher activity of nicotine metabolism was lower. In this study it was suggested that the CYP2A6AST;4C allele may prevent the carrier from smoking and the CYP2A6AST;1A/AST;1B heterozygote may be at risk for developing smoking behavior.
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