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Effect of advanced maternal age on early mortality among quadruplets and quintuplets
Hamisu M Salihu1, Muktar H Aliyu, Russell S Kirby
1Department of Maternal and Child Health, University of Alabama at Birmingham, AL 35294, USA. hsalihu@uab.edu
Objective:
This study was undertaken to determine whether advanced maternal age has an impact on survival among quadruplets and quintuplets.
Study Design:
A retrospective cohort study was performed on 1 448 quadruplets and 180 quintuplets delivered in the United States between 1995 and 1997. Infants of older mothers (> or =35 years old) were compared with those of younger ones (<35 years old) in terms of early mortality indices. Adjusted mortality probabilities were computed by yearly intervals of maternal age.
Results:
The likelihood for neonatal (odds ratio [OR]=2.00, 95% CI=1.20-3.45), perinatal (OR=2.10, 95% CI=1.32-3.23), and infant mortality (OR=2.13, 95% CI=1.28-3.60) was significantly higher among younger mothers. For each unit decrease in maternal age, the odds of stillbirth, neonatal, perinatal, and infant death went up by 9%, 12%, 13%, and 12%, respectively, in a dose-dependent fashion (P for trend <.0001).
Conclusion:
We found increasing maternal age to be associated with favorable survival outcomes among quadruplets and quintuplets.
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