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Published on: October 6, 2022
[The expression of urokinase-type plasminogen activator and its receptor in urinary transitional cell carcinoma]
Yan-Jiang Li1, Bao-zhong Zheng, Zun-lin Zhou
1Department of Urology, Qilu Hospital, Shandong University, Jinan 250012, China.
Objective:
To probe into the expression and clinical significance of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in urinary transitional cell carcinoma.
Methods:
Expression of uPA and uPAR were detected in 50 cases of renal pelvis and ureter carcinoma and 40 cases of bladder cancer immunohistochemically.
Results:
The positive rates of uPA and uPAR were closely correlated to the grade and the stage of urinary transitional cell carcinoma (r = 0.979, P < 0.01), whereas uPA and uPAR were not detected in normal kidney, ureter and bladder tissue.
Conclusion:
uPA and uPAR are highly expressed in urinary transitional cell carcinoma and they may be responsible for the tumor invasion and metastasis.
