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Updated: Aug 26, 2026
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Role of microsatellite instability in borderline ovarian tumors
M T Sanz Casla1, M Vidaurreta Lazaro, I Almansa de Lara
1Laboratory, Biology Department, Hospital Clinico San Carlos, C/Martin Lagos s/n, 28040 Madrid, Spain.
Abstract:
This study was designed to establish the role of microsatellite instability (MSI) in the development of sporadic tumors of the ovary. The instability of 6 microsatellites (BAT25, BAT26, NME1, D17S250, D5S346 and D2S123) was determined by comparing MSI in healthy and tumoral tissue in each of 40 patients undergoing surgery for a sporadic ovarian tumor. BAT26 and D2S123 instability was detected in borderline tumors, and ovarian carcinomas were found to present instability in the microsatellites BAT25, NME1 and D17S250. Our findings indicate that microsatellite instability lacks a significant role in the appearance or progression of sporadic ovarian tumors.
