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Prediction of boron concentrations in blood from patients on boron neutron capture therapy
Yasushi Shibata1, Akira Matsumura, Tetsuya Yamamoto
1Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Background:
In boron neutron capture therapy, blood boron concentration is the key factor to calculate radiation dose, however, blood sampling is difficult during neutron irradiation.
Materials And Methods:
The prediction of blood boron concentrations for BNCT treatment planning has been prospectively investigated using patient data obtained at first craniotomy after the infusion of a low dose of sodium undecahydroclosododecaborate.
Results:
The boron biodistribution data showed a biexponential pharmacokinetic profile. If the final boron concentration at 6 or 9 hours after the end of the infusion is within the 95% confidence interval of the prediction, direct prediction from biexponential fit will reduce the error of blood boron concentrations during irradiation to around 6%.
Conclusion:
Actual boron concentrations during BNCT were reasonably and accurately predictable from the test data.
