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Interpretation of subjective symptoms in double-blind placebo-controlled food challenges - interobserver reliability
M Gellerstedt1, J Magnusson, U Gråjö
1Department for Studies of Work, Economics and Health, the University of Trollhättan, Uddevalla, Sweden.
Background:
Subjective symptoms after food challenges are difficult to interpret and no standard is available. We discuss a strategy for how to interpret a diary. Furthermore, the interobserver reliability is evaluated.
Methods:
Diaries for 32 patients with subjective symptoms were used. The diaries were re-evaluated with a predefined strategy by three independent observers.
Results:
The proportion of positives was 21.9% among the old diagnoses, according to the new approach 34.4% (observers I and II) and 37.5% (observer III) were positive. The new approach had high interobserver reliability (97 and 100%).
Conclusions:
The proportion of positives depends on how subjective symptoms are interpreted. Interpretations of subjective symptoms in diaries could be made with high interobserver reliability.
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