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Low-dose granisetron for postoperative nausea and vomiting prophylaxis
Shelby L Corman1, Susan J Skledar, Nicole T Ansani
1University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USA. cormansl@msx.upmc.edu
The Annals of Pharmacotherapy
|February 26, 2004
Summary
Low-dose granisetron is not recommended for preventing postoperative nausea and vomiting due to insufficient evidence. Current guidelines for postoperative nausea and vomiting prophylaxis require further research for this low-dose regimen.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Postoperative nausea and vomiting (PONV) prophylaxis guidelines need revision due to safety concerns with droperidol and limited alternative agents.
- A new approach proposes using granisetron at a dose one-tenth of the FDA-approved level for PONV prophylaxis.
Purpose of the Study:
- To evaluate the efficacy and safety of low-dose granisetron for postoperative nausea and vomiting prophylaxis.
Main Methods:
- A comprehensive literature search was conducted using PubMed and OVID databases (1966-July 2003).
- Information from the granisetron manufacturer was also included in the evaluation.
Main Results:
- Evidence regarding the effectiveness of low-dose granisetron for PONV prophylaxis is conflicting.
- The study identified a scarcity of data to support the proposed low-dose regimen.
Conclusions:
- The use of low-dose granisetron is not recommended for PONV prophylaxis in at-risk patients.
- Further research is needed to establish the efficacy and safety of this regimen.