Related Experiment Video
Updated: Aug 26, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Nephrotoxic potential of selective cyclooxygenase-2 inhibitors
Gurbir K Sandhu1, Catherine A Heyneman
1College of Pharmacy, Idaho State University, Pocatello, ID 83209-8356, USA.
Objective:
To determine the relative nephrotoxic potential of cyclooxygenase (COX)-2 inhibitors.
Data Sources:
A MEDLINE search (1996-February 2004) identified clinical trials evaluating the nephrotoxicity of COX-2 inhibitors versus traditional nonsteroidal antiinflammatory drugs (NSAIDs). Key search terms included cyclooxygenase inhibitors, nonsteroidal antiinflammatory agents, nephrotoxicity, and chemically induced.
Data Synthesis:
Three clinical trials determined that COX-2 inhibitors have similar adverse effects on the kidney when compared with nonselective NSAIDs, while 2 studies concluded that COX-2 inhibitors are less nephrotoxic than nonselective NSAIDs. All 5 trials utilized low numbers of subjects, short-term therapy, and surrogate markers of kidney damage.
Conclusions:
COX-2 inhibitors may not offer distinct advantages over nonselective NSAIDs with respect to kidney function. Longer trials in patients with comorbidities are warranted. These agents should be used cautiously or not at all in patients with predisposing conditions.
More Related Videos
08:505/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
10:01Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Renal Drug Excretion: Overview
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules out...
Drug toxicity: Drug–Drug Interaction
Acute Kidney Injury II: Pathophysiology