Related Experiment Video
Updated: Aug 26, 2026
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
[Evaluation of TGF-beta1 expressed by oral and maxillofacial malignant neoplasm]
Qing Li1, Xiao-jian Zhou, Zhi-yuan Zhang
1Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Objective:
To investigate the relationship between the level of transforming growth factor beta I(TGF-beta(1)) in oral and maxillofacial malignant neoplasms and the biological characteristics of these carcinoma cells.
Methods:
The level of TGF-beta(1) in the carcinoma tissue cells, human tongue squamous cell carcinoma cell line Tca8113, human minor salivary gland carcinoma cell line ACC-2 and highly metastatic adenoid cystocarcinoma cell line ACC-M was measured by ELISA KIT.
Results:
The level of TGF-beta(1) in the carcinoma tissue cells had significant difference to that of normal cells(P<0.01). The level in Tca8113 and ACC-2 cells was significantly higher(P<0.05). Squamous cell carcinoma cell line Tca8113 had the same level of TGF-beta(1) as the adenoid cystocarcinoma cell line ACC-2, but the highly metastatic adenoid cystocarcinoma cells(ACC-M) expressed far less compared to ACC-2 cells (P<0.01). The level of TGF-beta(1) secreted by ACC-M cells to the culture without serum was also lower than that of any of the other carcinoma cells or normal cells.
Conclusion:
The level of TGF-beta(1) expression had significant relation to the proliferation, invasion and metastasis of oral and maxillofacial malignant neoplasms.
