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Updated: Aug 26, 2026
Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
[Quantitative assessment to the effect of HGAC treatments]
1Department of Orthodontics, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China. chenwei6048@sina.co
Objective:
To evaluate the treatment effect of skeletal class II malocclusion with HGAC.
Methods:
Seventeen skeletal Class II cases were selected and treated with HGAC, pre-treatment and post-treatment cephalometric radiographs were analyzed by Pancherz analysis.
Results:
Maxillary growth was inhibited by HGAC, especially in vertical direction. Mandibular retrognathism was improved significantly in horizontal direction. Meanwhile, the upper incisors were retruded and intruded.
Conclusion:
HGAC was effective in the correction of skeletal class II malocclusion.
