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A new insecticidal protolimonoid from Aegle marmelos.

J K R Radhika Samarasekera1, Bhupinder P S Khambay, K Patrick Hemalal

  • 1Biological Chemistry Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

Natural Product Research
|February 27, 2004
PubMed
Summary

Researchers discovered skimmiarepin C, a new senecioate ester, from the Aegle marmelos plant. This compound and skimmiarepin A show moderate insecticidal activity against common pests.

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Area of Science:

  • Natural Product Chemistry
  • Insect Toxicology
  • Phytochemistry

Background:

  • Aegle marmelos (Rutaceae) is a plant used in traditional medicine.
  • Natural products are a source of novel bioactive compounds.
  • Insecticides are crucial for pest management in agriculture and public health.

Purpose of the Study:

  • To isolate and identify bioactive compounds from Aegle marmelos stem bark.
  • To evaluate the insecticidal potential of isolated compounds.
  • To characterize a new senecioate ester analogue.

Main Methods:

  • Bioassay-directed fractionation of ethyl acetate extracts.
  • Spectroscopic methods (NMR, MS) for structural elucidation.
  • Insecticidal activity assays against Phaedon cochleariae and Musca domestica.

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Main Results:

  • Isolation of a new compound, skimmiarepin C, and known skimmiarepin A.
  • Skimmiarepin C is a senecioate ester analogue of skimmiarepin A.
  • Both skimmiarepin A and C demonstrated moderate insecticidal activity compared to pyrethrum.
  • Epimeric acetates of skimmiarepin C showed reduced activity.

Conclusions:

  • Aegle marmelos stem bark contains insecticidal compounds.
  • Skimmiarepin C represents a novel chemical structure with potential insecticidal properties.
  • Further research may explore structure-activity relationships for enhanced pest control agents.