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A cardiac transplant programme--the nurses role
The British Journal of Theatre Nursing : Natnews : the Official Journal of the National Association of Theatre Nurses
|July 1, 1992
Summary
The first heart transplant in 1967 faced challenges with rejection and infection. Cyclosporin
Area of Science:
- Cardiovascular Surgery
- Transplantation Immunology
- Medical History
Background:
- The inaugural human heart transplant in 1967 was followed by widespread challenges.
- Early attempts were hampered by significant rates of organ rejection and post-operative infections.
Purpose of the Study:
- To review the historical progression and key advancements in heart transplantation.
- To highlight the impact of immunosuppressive therapy and logistical improvements on patient outcomes.
Main Methods:
- Historical review of heart transplantation milestones.
- Analysis of developments in immunosuppression, rejection management, and organ procurement.
Main Results:
- Initial poor outcomes were gradually improved through better rejection detection and treatment strategies.
- The introduction of cyclosporin in 1983 dramatically reduced transplant-related mortality.
- Concurrent advancements in defining brain death and organ transport logistics facilitated wider application.
Conclusions:
- Heart transplantation has evolved significantly from its inception.
- Immunosuppression, particularly cyclosporin, and improved logistical frameworks have been pivotal in enhancing patient survival and quality of life.