Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pseudotumor cerebri.

Paul W Brazis1

  • 1Department of Neurology, Mayo Clinic-Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Brazis.paul@mayo.edu

Current Neurology and Neuroscience Reports
|February 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can Baseline Computed Tomography Scans Be Used to Identify Patients at High Risk of Vision Loss due to Terson Syndrome?

American journal of ophthalmology·2019
Same author

Myelin Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome.

American journal of ophthalmology·2018
Same author

The Electrical Properties of Gold Nanoparticle Assemblies Linked by DNA.

Angewandte Chemie (International ed. in English)·2018
Same author

Preoperative visual field deficits in temporal lobe epilepsy.

Epilepsy & behavior case reports·2017
Same author

A novel ANO3 variant identified in a 53-year-old woman presenting with hyperkinetic dysarthria, blepharospasm, hyperkinesias, and complex motor tics.

BMC medical genetics·2016
Same author

In Memoriam: Frank A. Rubino, MD.

JAMA neurology·2015
Same journal

Update on Genetic Chorea.

Current neurology and neuroscience reports·2026
Same journal

Gastrointestinal Dysfunction in Critically Ill Patients With Traumatic Brain Injury: Clinical Implications and Putative Mechanisms: a Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Potential of Rehabilitation to Amplify Experience-Induced Myelin Plasticity and Remyelination in Multiple Sclerosis: A Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Noradrenergic Brain in Parkinson's Disease.

Current neurology and neuroscience reports·2026
Same journal

Mapping the Silent Onset of Parkinson's Disease: Monoamine Imaging in the Era of the Race for Preclinical Intervention.

Current neurology and neuroscience reports·2026
Same journal

Functional and Structural Brain Imaging Correlates of Treatment Response in Functional Movement Disorder.

Current neurology and neuroscience reports·2026
See all related articles

Pseudotumor cerebri (PTC) involves increased intracranial pressure. Research suggests elevated CSF pressure may cause venous sinus pressure elevation, challenging previous theories on idiopathic PTC causes and treatment.

Area of Science:

  • Neurology
  • Neurosurgery
  • Ophthalmology

Background:

  • Pseudotumor cerebri (PTC) is characterized by increased intracranial pressure (ICP) without hydrocephalus or mass lesions.
  • While often termed 'idiopathic,' many PTC patients exhibit venous outflow abnormalities.
  • The role of venous sinus pressure in PTC pathogenesis is debated, with some studies suggesting it's a consequence, not a cause, of elevated ICP.

Purpose of the Study:

  • To review the current understanding of Pseudotumor cerebri (PTC) pathophysiology, focusing on the role of venous sinus pressure.
  • To discuss diagnostic and therapeutic strategies for PTC, including medical, surgical, and interventional options.
  • To evaluate the evidence for venous sinus stenting in managing refractory PTC cases.

Main Methods:

Related Experiment Videos

  • Literature review of studies investigating the etiology and management of Pseudotumor cerebri (PTC).
  • Analysis of the relationship between cerebrospinal fluid (CSF) pressure and intracranial venous sinus pressure.
  • Evaluation of treatment outcomes for various PTC interventions, including shunting, optic nerve sheath fenestration, and venous sinus stenting.

    • Main Results:

    • Evidence suggests that in idiopathic PTC, elevated CSF pressure may precede and cause increased venous sinus pressure.
    • Vitamin A toxicity is a potential contributing factor to idiopathic PTC.
    • Surgical interventions like lumboperitoneal shunts and optic nerve sheath fenestration are considered when medical therapy fails.

    Conclusions:

    • The causal relationship between venous sinus stenosis and idiopathic PTC remains uncertain; it may be a result rather than a cause.
    • The efficacy of primary treatment targeting venous stenosis in idiopathic PTC requires further investigation.
    • Management of PTC focuses on symptom alleviation and visual function preservation, with surgical options reserved for refractory cases.