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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
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Transcardiac increase in tumor necrosis factor-alpha and left ventricular end-diastolic volume in patients with

Takayoshi Tsutamoto1, Atsuyuki Wada, Masato Ohnishi

  • 1Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan. tutamoto@belle.shiga-med.ac.jp

European Journal of Heart Failure
|February 27, 2004
PubMed

Insights

Tumor necrosis factor-alpha (TNF-alpha) is secreted from failing hearts in patients with dilated cardiomyopathy (DCM). Elevated TNF-alpha correlates with left ventricular (LV) enlargement and dysfunction, indicating its role in heart remodeling.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • The role of cardiac-derived cytokines in heart failure remains unclear.
  • Investigating transcardiac gradients of cytokines and their link to left ventricular (LV) remodeling is crucial.

Purpose of the Study:

  • To evaluate the relationship between transcardiac cytokine gradients and LV volume/function in patients with dilated cardiomyopathy (DCM).

Main Methods:

  • Measured plasma levels of TNF-alpha and IL-6 in the aortic root (Ao) and coronary sinus (CS) of 60 DCM patients.
  • Analyzed correlations between transcardiac cytokine gradients and LV remodeling parameters.

Main Results:

  • No significant difference in IL-6 levels between Ao and CS.
  • Significantly higher TNF-alpha levels in CS compared to Ao.
  • Transcardiac TNF-alpha gradient correlated with LV end-diastolic volume index (LVEDVI) and LV ejection fraction.

Conclusions:

  • Elevated plasma TNF-alpha in DCM patients is partly derived from the failing heart.
  • TNF-alpha may play a role in the structural remodeling of the LV in DCM.
Abstract

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