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Updated: Aug 26, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Vaginal metastasis and thrombocytopenia from renal cell carcinoma
Jay E Allard1, John W McBroom, Christopher M Zahn
1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Walter Reed Army Medical Center and the National Naval Medical Center, Washington, DC, USA.
Background:
Vaginal cancer represents approximately 1-2% of genital tract malignancies. Most cases represent metastasis from the cervix, endometrium, or colon. Metastasis of renal cell carcinoma to the vagina is extremely rare.
Case:
A 58-year-old female presented with a bleeding vaginal lesion. Laboratory studies revealed severe thrombocytopenia, and radiological studies revealed a left renal mass; excision was consistent with metastatic renal cell carcinoma. A subsequent nephrectomy confirmed renal cell carcinoma. Postoperatively, the patient underwent immunotherapy and the thrombocytopenia resolved.
Conclusion:
We report the first case of metastatic renal cell carcinoma presenting as a vaginal metastasis with thrombocytopenia as a paraneoplastic manifestation. Renal cell carcinoma must be in the differential diagnosis of a clear cell neoplasm in a postmenopausal woman, particularly with systemic symptoms suggestive of a paraneoplastic syndrome.
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