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Infundibuloneurohypophysitis presenting a large sellar-juxtasellar mass: case report
Yukari Kanou1, Kazunori Arita, Kaoru Kurisu
1Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima, Japan.
Surgical Neurology
|February 27, 2004
Summary
Infundibuloneurohypophysitis (INH) can present as a large sellar mass compressing the brainstem. This inflammatory condition, though rare, showed significant improvement with radiation and corticosteroid treatment.
Area of Science:
- Neuroendocrinology
- Pathology
Background:
- Infundibuloneurohypophysitis (INH) is an inflammatory condition affecting the neurohypophysis.
- It is typically considered self-limiting, but can present with significant mass effect.
Observation:
- A patient presented with polyuria, hemiparesis, and dysarthria.
- MRI revealed a large sellar mass compressing the brainstem, with diagnosed diabetes insipidus.
- Histopathology showed lymphoid cell infiltration, predominantly B cells.
Findings:
- The sellar mass significantly decreased in size following radiation therapy and corticosteroid administration.
- The patient achieved neurological recovery within six months and remained disease-free at 67 months.
Implications:
- INH exhibits a broad clinical spectrum, ranging from small lesions to aggressive masses.
- This case highlights the potential for significant mass effect and the efficacy of multimodal treatment.