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Gene mutation of thiopurine S-methyltransferase in Uygur Chinese
Jian-Ping Zhang1, Yong-Yuan Guan, An-Long Xu
1Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, 74 Zhongshan Road, Section 2, 510080 Guangzhou, P.R. China.
Objective:
This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese.
Methods:
Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations-G238C, G460A and A719G.
Results:
One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively.
Conclusion:
TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese.
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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Translation Produces the Building Blocks of Life
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