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Updated: Aug 26, 2026

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units
Pierre Delanaye1, Bernard Lambermont, Jean-Paul Chapelle
1Nephrology, Department of Medicine, Liege University Hospital, CHU Sart Tilman (B35), 4000 Liege, Belgium.
Objective:
To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.
Design:
Prospective observational study.
Setting:
Medical intensive care unit at a university hospital.
Patients And Participants:
Fourteen patients hospitalised in a medical intensive care unit.
Interventions:
Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h.
Measurements And Results:
Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m(2) was significantly better than that of creatinine ( p<0.05).
Conclusions:
Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future.
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