Related Experiment Video
Updated: Aug 26, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
[Halothane-induced hepatitis. 8 case reports]
Riadh Daghfous1, Sihem el Aïdli, Mohamed Sfaxi
1Centre National de Pharmacovigilance, Hôpital Charles Nicolle, Tunis.
Abstract:
Halothane (Fluothane) is a halogenic volatile anaesthetic used in therapeutic since 1956. His adverse effects are generally moderate with the exception of hepatitis that is usually severe and sometimes fatal. In our study, we analyze 8 cases of halothane-induced hepatitis, notified in the Centre National de Pharmacovigilance between 1994 and 1999 and validate according to B. Bégaud and collaborators method of imputability. It concerns 5 women and 3 men, aged between 26 and 65 years. The injury was cytolytic in 6 cases and cholestatic in the 2 others. It was fulminant in 3 cases of which 2 leaded to death. These injuries are usually graves, with an unforeseeable appearance and a hypothetical mechanism. In our opinion, a liver function control is necessary at the time of utilization of this drug.
Related Concept Videos
Hepatitis
Cirrhosis I: Introduction
Viral Hepatitis I: Introduction
Hepatic Encephalopathy
Inhalational Anesthetics: Overview
Cirrhosis II: Pathophysiology
