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Boric acid catalyzed chemoselective esterification of alpha-hydroxycarboxylic acids
Todd A Houston1, Brendan L Wilkinson, Joanne T Blanchfield
1School of Science, Griffith University, Nathan, Queensland 4111, Australia. t.houston@griffith.edu.au
Organic Letters
|February 28, 2004
Abstract:
Boric acid catalyzes the selective esterification of alpha-hydroxycarboxylic acids without causing significant esterification to occur with other carboxylic acids. The procedure is simple, high-yielding, and applicable to the esterification of alpha-hydroxy carboxylates in the presence of other carboxylic acids including beta-hydroxyacids within the same molecule. [reaction: see text]