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Bioactive constituents from Asparagus cochinchinensis
Hong-Jie Zhang1, Kongmany Sydara, Ghee Teng Tan
1Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy (M/C877), College of Pharmacy, the University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
Journal of Natural Products
|February 28, 2004
Summary
Researchers isolated novel compounds from Asparagus cochinchinensis roots, including a spirostanol saponin and unique steroids. Some compounds showed moderate cytotoxicity against cancer and endothelial cell lines.
Area of Science:
- Natural Product Chemistry
- Pharmacognosy
- Medicinal Chemistry
Background:
- Asparagus cochinchinensis is a traditional medicinal plant.
- Phytochemical investigation of Asparagus species can yield bioactive compounds.
Purpose of the Study:
- To isolate and characterize novel chemical constituents from Asparagus cochinchinensis roots.
- To evaluate the cytotoxic potential of isolated compounds.
Main Methods:
- Bioassay-directed fractionation of plant extracts.
- Structure elucidation using spectroscopic (NMR, MS) and chemical methods.
- Cytotoxicity assays against a panel of human cancer and endothelial cell lines.
Main Results:
- Isolation of a new spirostanol saponin (asparacoside), two new C-27 spirosteroids (asparacosins A and B), a new acetylenic derivative (3''-methoxyasparenydiol), and a new polyphenol (3'-hydroxy-4'-methoxy-4'-dehydroxynyasol).
- Identification of five known phenolic compounds.
- Compounds 1, 6, and 8 exhibited moderate cytotoxicities with IC(50) values between 4-12 microg/mL against KB, Col-2, LNCaP, Lu-1, and HUVEC cells.
Conclusions:
- The study successfully identified several new compounds from Asparagus cochinchinensis.
- The isolated compounds asparacoside, 3'-hydroxy-4'-methoxy-4'-dehydroxynyasol, and 3''-methoxynyasol possess moderate cytotoxic activity, warranting further investigation.