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Updated: Aug 9, 2026

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium
Published on: November 21, 2014
The effect of hypertonic saline dextran on whole blood coagulation
Timothy John Coats1, Mischa Heron
1Department of Accident and Emergency, Barts and the London, Queen Mary's School of Medicine, University of London, Royal London Hospital, Whitechapel, London E1 1BB, UK. t.j.coats@qmul.ac.uk
Abstract:
Hypertonic saline dextran (RescueFlow) is being promoted for resuscitation from hypovolaemia following injury. We studied the in vitro effect on coagulation of serial dilutions of blood with this fluid. There was a mild procoagulant effect up to a dilution of 11% and an anticoagulant effect above this level, which rapidly increased so that coagulation was grossly deranged at a 15% dilution. Although the clinical significance of these findings is not yet known, it may suggest that for hypertonic saline dextran there is little to separate the top of the therapeutic window from the threshold of potentially serious adverse effects.
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