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Updated: Aug 26, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and cytotoxic effect of carbocyclic potential minor groove binders
Danuta Bartulewicz1, Tomasz Anchim, Milena Dabrowska
1Department of Organic Chemistry, Medical University of Białystok, Mickiewicza 2a, Białystok 15222, Poland. dbartule@amb.edu.pl
Abstract:
New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic alpha,omega-diamines with three, four and five methylene fragments. The half structures, compounds IV-VI can be compared to bis-amidines, compounds X-XII to bis-netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7.
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