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Attempted transmission of Entamoeba coli to specified-pathogen-free rodents

D Owen

    Laboratory Animals
    |April 1, 1978
    PubMed

    Insights

    Human Entamoeba coli transmission to rodents is limited. Cysts from human and primate stool were passaged into guinea pigs, rats, and mice, with successful establishment only occurring in mice and subsequently rats in one instance.

    Area of Science:

    • Parasitology
    • Infectious Diseases
    • Zoonotic Research

    Background:

    • Entamoeba coli is a common non-pathogenic intestinal protozoan parasite in humans.
    • Understanding potential transmission routes is crucial for public health and research.

    Purpose of the Study:

    • To investigate the transmissibility of human Entamoeba coli to laboratory rodent models.
    • To assess the suitability of rodents for Entamoeba coli research.

    Main Methods:

    • Cysts of Entamoeba coli were isolated from 15 human and 4 primate stool samples.
    • These cysts were experimentally passaged into specified-pathogen-free (SPF) guinea pigs, rats, and mice.
    • Infection establishment was monitored in the inoculated rodents.

    Main Results:

    • Successful transmission and establishment of Entamoeba coli were observed in only one experimental instance.
    • In this single case, infection was first established in mice and later in rats.
    • Guinea pigs did not show successful cyst establishment in this study.

    Conclusions:

    • Laboratory rodents, specifically mice and rats, show limited susceptibility to human Entamoeba coli.
    • The transmissibility of Entamoeba coli from humans to common laboratory rodents is generally low.
    • Further research may be needed to identify specific strains or conditions that could facilitate rodent infection.

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