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A Danish diabetes risk score for targeted screening: the Inter99 study
Charlotte Glümer1, Bendix Carstensen, Annelli Sandbaek
1Steno Diabetes Centre, Gentofte, Denmark. chgl@steno.dk
Diabetes Care
|February 28, 2004
Summary
A new questionnaire effectively identifies individuals with undiagnosed diabetes, achieving 76% sensitivity. This tool aids in efficient screening, reducing unnecessary follow-up tests for type 2 diabetes detection.
Area of Science:
- Endocrinology
- Public Health
- Epidemiology
Background:
- Undiagnosed diabetes poses significant health risks and contributes to healthcare costs.
- Effective screening tools are crucial for early detection and management of type 2 diabetes.
Purpose of the Study:
- To develop a simple, self-administered questionnaire for identifying individuals with undiagnosed diabetes.
- To achieve a sensitivity of 75% while minimizing the proportion of individuals requiring further testing.
Main Methods:
- A population-based sample of 6,784 individuals (aged 30-60) completed a questionnaire and underwent an oral glucose tolerance test.
- A risk score was developed using logistic regression and validated internally and externally.
- The final risk score incorporated age, sex, BMI, hypertension, physical activity, and family history.
Main Results:
- The final risk score included age, sex, BMI, hypertension, physical activity, and family history of diabetes.
- The model achieved an area under the receiver operating curve of 0.761-0.804 across validation sets.
- Sensitivity was 76%, specificity 72%, with 29% requiring subsequent testing.
Conclusions:
- A validated questionnaire can be used in a stepwise screening strategy for type 2 diabetes.
- This approach can reduce the number of individuals needing further tests, potentially lowering screening costs.