Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aortic valve replacement in patients with severely reduced left ventricular function.

Subroto Paul1, Tomislav Mihaljevic, James D Rawn

  • 1Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.

Cardiology
|February 28, 2004
PubMed
Summary

Aortic valve replacement (AVR) is a safe and effective treatment for severe aortic stenosis or regurgitation with reduced ejection fraction. This procedure offers similar survival rates to heart transplantation, making it a preferred option for eligible patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Definitive Repair After Staged Hybrid Procedure of the Ascending Aorta and Aortic Valve Redo Surgery for Kinked Aortic Graft.

The Annals of thoracic surgery·2026
Same author

Intubation Injury of Left Mainstem Bronchus During Right-Sided Lung Resection: Assessment and Repair.

Innovations (Philadelphia, Pa.)·2026
Same author

A real-time rapid cycle process improvement tool for accelerated quality improvement in coronary artery bypass grafting surgery.

JTCVS open·2025
Same author

Single center experience of laser tracheobronchoplasty and review of the literature.

Expert review of respiratory medicine·2025
Same author

Laparoscopic robotic-assisted transhiatal thoracic duct ligation for refractory chylothorax.

JTCVS techniques·2024
Same author

Left Thoracoscopic Robot-Assisted Excision of a Left Lower Paratracheal Parathyroid Adenoma for Cure of Primary Hyperparathyroidism.

Innovations (Philadelphia, Pa.)·2024

Area of Science:

  • Cardiovascular Surgery
  • Cardiac Anesthesia
  • Cardiology

Background:

  • Severe aortic stenosis (AS) and aortic regurgitation (AR) in patients with depressed ventricular function (ejection fraction ≤35%) pose significant management challenges.
  • Traditional treatment paradigms may not adequately address the risks and benefits in this high-risk patient cohort.
  • Identifying patients with contractile reserve is crucial for optimizing outcomes.

Purpose of the Study:

  • To evaluate the safety and efficacy of aortic valve replacement (AVR) in patients with severe AS and depressed ventricular function.
  • To assess the utility of dobutamine echocardiography for risk stratification and identifying patients who benefit from AVR.
  • To compare AVR outcomes with orthotopic heart transplantation in this population.

Main Methods:

Related Experiment Videos

  • Retrospective analysis of patients with severe AS and depressed ventricular function undergoing AVR.
  • Utilized dobutamine echocardiography to assess myocardial contractile reserve.
  • Compared survival rates and operative mortality between AVR and orthotopic heart transplantation.

Main Results:

  • AVR can be performed safely in patients with severe AS and ejection fraction ≤35%, with acceptable operative mortality.
  • Dobutamine echocardiography effectively identifies patients with contractile reserve who are likely to benefit from AVR.
  • Five-year survival rates for AVR in both severe AS and severe AR with depressed function approximate 70%, comparable to heart transplantation.

Conclusions:

  • AVR is a viable and safe therapeutic option for patients with severe aortic valve disease and depressed ventricular function.
  • Dobutamine echocardiography serves as a valuable tool for patient selection and risk stratification prior to AVR.
  • Given the risks associated with immunosuppression and donor organ scarcity, AVR should be considered before heart transplantation in these high-risk groups.