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Ocular side effects associated with isotretinoin
1National Registry of Drug-Induced Ocular Side Effects, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon 97201-4197, USA. eyedrug@ohsu.edu
Drugs of Today (Barcelona, Spain : 1998)
|February 28, 2004
Summary
Isotretinoin, used for severe acne, can cause ocular side effects like dry eyes and vision changes. This review confirms dry eye, poor dark adaptation, and intracranial hypertension as certain side effects.
Area of Science:
- Ophthalmology
- Dermatology
- Pharmacovigilance
Background:
- Isotretinoin is a common treatment for severe recalcitrant nodular acne.
- Ocular side effects are a known concern associated with isotretinoin therapy.
- Understanding and classifying these side effects is crucial for patient safety.
Purpose of the Study:
- To classify the ocular side effects of isotretinoin based on World Health Organization (WHO) criteria.
- To review existing literature and spontaneous case reports concerning isotretinoin's ocular adverse events.
- To provide clinical guidelines for managing and monitoring these side effects.
Main Methods:
- Systematic review of the existing medical literature.
- Analysis of 2449 spontaneous case reports of isotretinoin-associated ocular side effects.
- Classification of side effects using World Health Organization (WHO) criteria.
Main Results:
- Ocular sicca (dry eye), decreased dark adaptation, and intracranial hypertension were identified as "certain" ocular side effects.
- The review synthesized data from literature and a large global dataset of case reports.
- Specific patterns and frequencies of ocular adverse events were observed.
Conclusions:
- Clinicians should be aware of the potential for specific ocular side effects with isotretinoin use.
- Monitoring for ocular sicca, decreased dark adaptation, and intracranial hypertension is recommended.
- Established guidelines for patient care and follow-up are essential for managing isotretinoin-induced ocular complications.