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Membranous glomerulonephritis associated with hepatitis C virus infection: case report and literature review

Y Uchiyama-Tanaka1, Y Mori, N Kishimoto

  • 1Renal Division, Department of Medicine II, Kansai Medical University, Moriguchi, Osaka, Japan.

Clinical Nephrology
|March 3, 2004
PubMed

Insights

Hepatitis C virus (HCV) infection can cause membranous glomerulonephritis, a kidney disease. This case study found virus-like particles in kidney tissue, suggesting direct HCV involvement in kidney damage.

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) infection is a global health concern.
  • Kidney involvement in HCV infection is well-documented, often presenting as glomerulonephritis.
  • Immune complex-mediated glomerulonephritis is a common renal manifestation of HCV.

Observation:

  • A 51-year-old man with HCV presented with facial edema and normal renal function.
  • Renal biopsy revealed membranous glomerulonephritis with positive HCV antibody and cryoglobulin.
  • Electron microscopy identified virus-like particles in glomerular deposits, suggesting direct HCV presence.

Findings:

  • The patient exhibited normocomplementemia and positive circulating immune complexes containing HCV RNA.
  • The presence of La/SS-B antibody indicated an abnormal immune response linked to HCV.
  • Histopathological findings suggest HCV-associated immune complex-mediated glomerulonephritis.

Implications:

  • This case highlights the potential for direct viral involvement in HCV-related kidney disease.
  • Early detection and treatment of HCV are crucial to prevent renal complications.
  • Therapeutic strategies involving pegIFN-alpha2a and ribavirin may improve clinical and histopathological outcomes.

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