Preimplantation genetic diagnosis for Y-linked diseases: why not?

The introduction of intracytoplasmic sperm injection (ICSI) has allowed men with severe oligozoospermia and non-obstructive azoospermia to achieve fertilization and parenthood. A significant number of these men have translocation defects affecting the long arm of the Y chromosome. Chromosomal anomalies are considered to be a major contributor to the genetic risks of fertilization treatment by ICSI. The most frequently documented genetic cause of male infertility is Y-chromosome deletions, which have been shown to be transmitted to 100% of male offspring. It is appropriate to open a debate on the use of preimplantation genetic diagnosis with ICSI for severe male factor associated with Y-chromosome aberrations.