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Published on: November 8, 2024
[Circulating endothelial cells and hepatocyte growth factor in patients with pregnancy induced hypertension]
Yan Wang1, Tao Shang, Wei-wei Tang
1Department of Obstetrics and Gynecology, Second Hospital, China Medical University, Shenyang 110004, China.
Objective:
To investigate the relationship between hepatocyte growth factor (HGF) and vascular endothelial cells (VEC) in pregnancy induced hypertension (PIH).
Methods:
Twenty women with PIH (6 mild, and 14 moderate or severe PIH) and 20 women with normal pregnancy were recruited as study group and control group, respectively. The two groups were matched in maternal age, parity and gestational age. Flow cytometer was used for counting the number of peripheral blood circulating endothelial cells (CEC), while enzyme-linked immunoabsorbent assay (ELISA) was used to measure the concentration of serum HGF.
Results:
In the study group, the concentration of HGF was (1395 +/- 512) ng/L, and the number of CEC was (109,360 +/- 24,070) /L. In the control group, the concentration of HGF was (1565 +/- 399) ng/L, and the number of CEC was (21,800 +/- 4420)/L. The differences both in the concentration of HGF and the number of CEC between the two groups were statistically significant (P < 0.01). Negative correlation between CEC and HGF was found both in study group and control group (r = -0.608, P < 0.01).
Conclusion:
Decreased HGF may be related to VEC damage in the development of PIH.
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