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Published on: February 21, 2018
[Expression of BP1 gene in adult acute leukemia]
Hui Li1, Kai-lin Xu, Xiu-ying Pan
1Department of Hematology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China.
Objective:
To explore the expression of beta protein 1 (BP1) gene in adult acute leukemia (AL) and its relationship with acute leukemia.
Methods:
Expression of BP1 gene mRNA was detected in 70 adult AL, 10 normal controls and HEL cell line, by reverse transcriptase-polymerase chain reaction (RT-PCR).
Results:
No detectable BP1 gene was found in peripheral blood or bone marrow cells of normal controls and 20 acute myeloid leukemia (AML) in complete remission (CR) stage. BP1 gene was highly expressed in HEL cell line, 57% (20/35) of AML and 80% (8/10) of AML-M(5) cases. BP1 gene could not be detected in adult acute lymphoid leukemia.
Conclusion:
BP1 gene was highly expressed in AML. It might be used as a molecular marker of AML.
