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Related Experiment Videos

The autotransporter secretion system.

Mickaël Desvaux1, Nicholas J Parham, Ian R Henderson

  • 1Bacterial Pathogenesis and Genomics Unit, Division of Immunity and Infection, The Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Research in Microbiology
|March 3, 2004
PubMed
Summary

The type V secretion system comprises autotransporter, two-partner, and Oca families. This review details the autotransporter process, including precursor translocation across membranes via a beta-barrel pore.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Protein Secretion

Background:

  • The type V secretion system is a crucial pathway for protein export in Gram-negative bacteria.
  • This system encompasses diverse families, including autotransporters, two-partner secretion systems, and the Oca family.

Purpose of the Study:

  • To review the intricate mechanism of the autotransporter secretion pathway.
  • To elucidate the step-by-step process of protein translocation in type V secretion.

Main Methods:

  • Literature review focusing on molecular mechanisms of protein transport.
  • Analysis of established models for bacterial secretion systems.

Main Results:

  • The autotransporter pathway involves sequential translocation of precursor proteins across the inner and outer bacterial membranes.

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  • Outer membrane translocation is facilitated by a pore-forming beta-barrel structure.

    • Conclusions:

    • The type V secretion system, particularly the autotransporter family, employs a sophisticated mechanism for extracellular protein delivery.
    • Understanding this process is vital for comprehending bacterial pathogenesis and developing novel therapeutic strategies.