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Related Experiment Videos

[Aortitis after G-CSF injections].

C Darie1, S Boutalba, P Fichter

  • 1Service de cardiologie, hôpital de Valence, 179, boulevard du Maréchal-Juin, 26953 Valence cedex 9, France. dariec2001@yahoo.fr

La Revue De Medecine Interne
|March 3, 2004
PubMed
Summary
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Granulocyte-colony stimulating factor (G-CSF) injections may cause acute aortitis, a rare aortic inflammation. Prompt corticosteroid treatment led to a favorable outcome, highlighting a potential link between G-CSF and aortic lesions.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • Aortitis is aortic wall inflammation with potential for life-threatening aneurysm and rupture.
  • Causes of aortitis can be infectious or non-infectious and sometimes remain obscure.

Observation:

  • A 55-year-old woman developed acute aortitis of the descending aorta following G-CSF injections for stem cell transplantation.
  • No other cause for the aortitis was identified.

Findings:

  • The patient's aortitis resolved favorably with corticosteroid treatment.
  • No aortic aneurysm was detected at the six-month follow-up.

Implications:

  • This case suggests a potential role for G-CSF in the pathogenesis of aortic lesions.

Related Experiment Videos

  • G-CSF-induced neutrophil abnormalities may contribute to diseases like aortitis, similar to other reported neutrophilic conditions.