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Updated: Aug 26, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication
Patrizia Caposio1, Michel Dreano, Gianni Garotta
1Department of Public Health and Microbiology, University of Torino, Turin, Italy.
Abstract:
Human cytomegalovirus (HCMV) exploits the host transcription factor NF-kappaB to enhance its own replication, dissemination, and reactivation from latency. Here we report that HCMV infection activates the upstream IkappaB kinase (IKK) complex and that its catalytic IKK2 subunit is required for HCMV-induced NF-kappaB activation, as well as the replication of different HCMV strains. These results indicate that IKK2 is essential for HCMV replication and emphasize the feasibility of blocking NF-kappaB activation as a way of inhibiting infection.
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