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Cerebral blood volume in T2-weighted white matter hyperintensities using exogenous contrast based perfusion MRI

Perminder Sachdev1, Wei Wen, Ron Shnier

  • 1Department of Neuropsychiatry, University of New South Wales, Sydney, Australia. p.sachdev@unsw.edu.au

The Journal of Neuropsychiatry and Clinical Neurosciences
|March 3, 2004
PubMed

Insights

White matter hyperintensities (WMH) show reduced cerebral blood volume, particularly in larger lesions. This indicates microvascular issues affecting blood flow in aging brains, seen in both stroke patients and healthy individuals.

Area of Science:

  • Neuroimaging
  • Cerebrovascular Health
  • Geriatric Medicine

Background:

  • White matter hyperintensities (WMH) are common in aging and associated with cerebrovascular disease.
  • Understanding the hemodynamic status of WMH is crucial for assessing their impact.

Purpose of the Study:

  • To investigate relative regional cerebral blood volume (rCBV) in WMH using perfusion MRI.
  • To compare rCBV in WMH between elderly stroke patients and healthy controls.

Main Methods:

  • Perfusion-weighted magnetic resonance imaging (MRI) was used to measure rCBV.
  • T2-weighted FLAIR MRI identified WMH anatomy.
  • Gadolinium-DTPA bolus tracking assessed perfusion.

Main Results:

  • WMH demonstrated significantly lower rCBV compared to normal white matter.
  • Reduced rCBV correlated with WMH size.
  • Larger WMH showed increased rCBV from core to periphery, suggesting heterogeneous hemodynamic changes.

Conclusions:

  • WMH exhibit hemodynamic perturbations in their microvasculature.
  • These microvascular changes are size-dependent and present in both stroke patients and healthy older adults.
  • Findings highlight impaired cerebral blood flow within WMH regions.

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