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Related Experiment Videos

[Evaluating multislice computed tomography for imaging coronary atherosclerosis].

K Nikolaou1, C R Becker, B J Wintersperger

  • 1Institut für Klinische Radiologie, Klinikum der Universität München - Standort Grosshadern. Konstantin.Nikolaou@ikra.med.uni-muenchen.d

Der Radiologe
|March 3, 2004
PubMed
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Multidetector-row computed tomography (MDCT) effectively assesses coronary artery atherosclerosis by differentiating plaque types ex vivo and detecting noncalcified plaques in vivo. This imaging technique aids in evaluating vessel wall changes and plaque burden.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Pathology

Background:

  • Atherosclerotic coronary artery disease (CAD) is a leading cause of mortality.
  • Accurate assessment of coronary artery plaque burden and composition is crucial for risk stratification.
  • Multidetector-row computed tomography (MDCT) offers potential for non-invasive evaluation of coronary atherosclerosis.

Purpose of the Study:

  • To evaluate the efficacy of MDCT in assessing atherosclerotic changes in coronary artery vessel walls.
  • To develop and validate imaging criteria for different plaque types using MDCT.
  • To assess the in vivo diagnostic performance of MDCT coronary angiography (MDCTA) for plaque detection and characterization.

Main Methods:

  • Ex vivo study: 17 human hearts scanned with MDCT and compared to histopathology.

Related Experiment Videos

  • Development of MDCT morphologic imaging criteria for lipid-rich, fibrous, and calcified plaques.
  • In vivo study: Retrospective review of 94 coronary MDCT angiograms (MDCTA) for plaque assessment and volumetry.

    • Main Results:

    • MDCT demonstrated high sensitivity for detecting calcified and non-calcified plaques ex vivo.
    • Histopathology correlation enabled determination of characteristic MDCT criteria for plaque components.
    • In vivo MDCTA identified noncalcified plaques in 38% of patients, even in those with a calcium score of 0.

    Conclusions:

    • MDCT can differentiate various coronary plaque components both ex vivo and in vivo.
    • Contrast-enhanced MDCT is effective for detecting noncalcified coronary plaques.
    • In vivo plaque volumetry using MDCT is technically feasible.