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MRI and PET in Mouse Models of Myocardial Infarction
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[Determining myocardial viability in myocardial infarct. Comparison of single and multisclice MRI techniques with

A Huber1, S O Schönberg, B Spannagl

  • 1Institut für Klinische Radiologie, Klinikum Grosshadern der Ludwig-Maximilians-Universität München. Armin.Huber@ikra.med.uni-muenchen.de

Der Radiologe
|March 3, 2004
PubMed
Abstract

Insights

The inversion recovery 2D single shot TrueFisp sequence accurately detects myocardial infarction extent and area. While having a lower contrast-to-noise ratio than IR-TurboFlash, it offers comparable diagnostic accuracy for infarct assessment.

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Myocardial Infarction

Background:

  • Assessing myocardial viability is crucial for managing heart attack patients.
  • Established techniques like inversion recovery TurboFlash (IR-TF) are used for cardiac MRI.
  • Novel sequences aim to improve imaging efficiency and diagnostic accuracy.

Purpose of the Study:

  • To compare the diagnostic accuracy of a multislice inversion recovery 2D single shot TrueFisp (IR-TFI) sequence against the established IR-TurboFlash (IR-TF) sequence for imaging myocardial viability.
  • To evaluate the ability of both sequences in assessing infarct size and transmural extent.

Main Methods:

  • Twelve patients with myocardial infarction underwent cardiac MRI at 1.5 tesla after contrast agent administration.
  • Imaging was performed using both a multislice 2D IR-TFI sequence (one breathhold for the entire short axis) and a 2D single slice IR-TF technique (one breathhold per slice).
  • Signal intensity, contrast-to-noise ratio, and infarct areas were analyzed for both sequences.

Main Results:

  • The IR-TFI sequence demonstrated a lower contrast-to-noise ratio (6.9) compared to IR-TF (12.5) for viable and non-viable myocardium.
  • Excellent correlation (r=0.97) was found between both techniques for assessing infarct volume.
  • Identical spatial resolution allowed for accurate assessment of the transmural extent of infarction with both sequences.

Conclusions:

  • The inversion recovery 2D single shot TrueFisp technique provides accurate detection and delineation of myocardial infarction.
  • This sequence enables precise determination of infarct area and assessment of its transmural extent with high spatial resolution.
  • IR-TFI offers a potentially more efficient imaging approach for evaluating myocardial infarction compared to traditional single-slice techniques.

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