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Criteria for skin notation in different countries.

Jesper B Nielsen1, Philippe Grandjean

  • 1Institute of Public Health, University of Southern Denmark, DK-5000 Odense C, Denmark. jbnielsen@health.sdu.dk

American Journal of Industrial Medicine
|March 3, 2004
PubMed
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Skin notations for industrial chemicals, a qualitative hazard indicator, lack quantitative measures for effective prevention. Discrepancies in criteria across countries highlight the need for a new risk assessment approach.

Area of Science:

  • Occupational Health and Safety
  • Toxicology
  • Industrial Hygiene

Background:

  • Skin notation criteria, established nearly 50 years ago, qualitatively indicate dermal absorption hazards.
  • Risk assessment necessitates quantitative measures for effective prevention, moving beyond qualitative indicators.
  • Several countries have developed alternative criteria for assigning skin notations to industrial chemicals.

Purpose of the Study:

  • To compare the current application of skin notations in occupational exposure limit lists across six countries.
  • To analyze the variations in criteria used for assigning skin notations to industrial chemicals.
  • To identify discrepancies in skin notation assignment despite comparable occupational exposure limits (OELs).

Main Methods:

  • Comparative analysis of skin notation criteria and usage.

Related Experiment Videos

  • Review of industrial chemical lists and associated exposure limits from six countries.
  • Examination of factors influencing skin notation assignment.

    • Main Results:

    • Up to one-third of listed industrial chemicals currently carry a skin notation.
    • Significant discrepancies exist in the criteria for assigning skin notations among countries.
    • These differing criteria do not fully explain the observed variations in skin notation prevalence, even with comparable OELs.

    Conclusions:

    • The rising number of chemicals with skin notations demands a refined approach to risk differentiation.
    • Addressing the inconsistencies in skin notation assignment criteria is a critical first step.
    • Further research should investigate the impact of penetration enhancers and chemical mixtures on dermal absorption risk.