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Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus
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Delayed myotoxicity in snake envenoming by the tiger snake group

Christopher F Gavaghan1, Geoffrey Sparkes

  • 1Emergency Department, Lismore Base Hospital, PO Box 419, Lismore, NSW 2480, Australia. chrisg@nrhs.health.nsw.gov.au

Emergency Medicine (Fremantle, W.A.)
|March 3, 2004
PubMed

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...