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Published on: May 25, 2012
Next-generation hydrogel films as tissue sealants and adhesion barriers
Steven L Bennett1, David A Melanson, David F Torchiana
1Confluent Surgical, Inc., 101 A First Ave, Waltham, MA 02451, USA.
Journal of Cardiac Surgery
|March 3, 2004
Summary
A novel sprayable hydrogel film effectively seals blood vessels and prevents adhesions, demonstrating dual function as a surgical sealant and adhesion barrier in preclinical cardiovascular models.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Regenerative Medicine
Background:
- Development of sprayable, tissue-adherent hydrogel films enables new products for surgical applications.
- These hydrogel films offer dual functionality as hemostatic sealants and anti-adhesion barriers.
Purpose of the Study:
- Evaluate a sprayable, in situ formed absorbable hydrogel film.
- Assess its efficacy as a tissue sealant in a canine carotid artery graft model.
- Determine its effectiveness as an adhesion barrier in a rabbit pericardial abrasion model.
Main Methods:
- Hydrogel film applied to leaking PTFE grafts in canine carotid artery anastomoses.
- Hemostasis evaluated after restoration of blood flow.
- Hydrogel film applied in a rabbit pericardial abrasion model to assess adhesion prevention.
Main Results:
- The sprayable hydrogel film successfully sealed all six tested carotid-PTFE anastomoses immediately.
- A statistically significant reduction in the number and tenacity of adhesions was observed in the rabbit pericardial abrasion model.
Conclusions:
- The novel in situ formed sprayable hydrogel film functions effectively as both a tissue sealant and an adhesion barrier.
- This synthetic biomaterial shows promise in cardiovascular preclinical models and is undergoing clinical investigation.
