Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Stem cells and liver replacement].

Fred Fändrich1, Maren Ruhnke

  • 1Klinik für Allgemeine Chirurgie und Thoraxchirurgie, Universitätsklinikum Schleswig-Holstein, Campus Kiel. ffaendrich@surgery.uni-kiel.de

Medizinische Klinik (Munich, Germany : 1983)
|March 3, 2004
PubMed
Summary

Stem cell programmability offers future clinical strategies for tissue repair and genetic diseases. This review surveys stem cell applications for liver diseases, considering biological, ethical, and clinical parameters.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secretory products from regulatory macrophages modulate senescence in human endothelial cells: implications for cardiovascular aging and diseases.

BMC cardiovascular disorders·2026
Same author

Transcriptomic characterization of GMP-compliant regulatory macrophages (TRI-001) under inflammatory and hypoxic conditions: a comparative analysis across macrophage subtypes.

Journal of translational medicine·2025
Same author

Effects of temporal IFNγ exposure on macrophage phenotype and secretory profile: exploring GMP-Compliant production of a novel subtype of regulatory macrophages (Mreg<sub>IFNγ0</sub>) for potential cell therapeutic applications.

Journal of translational medicine·2024
Same author

Large extracellular vesicles derived from human regulatory macrophages (L-EV<sub>Mreg</sub>) attenuate CD3/CD28-induced T-cell activation in vitro.

Journal of molecular medicine (Berlin, Germany)·2023
Same author

Characterization of large extracellular vesicles (L-EV) derived from human regulatory macrophages (Mreg): novel mediators in wound healing and angiogenesis?

Journal of translational medicine·2023
Same author

Effects of remote ischemic preconditioning (RIPC) and chronic remote ischemic preconditioning (cRIPC) on levels of plasma cytokines, cell surface characteristics of monocytes and in-vitro angiogenesis: a pilot study.

Basic research in cardiology·2021

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Hepatology

Background:

  • Stem cell programmability, encompassing embryonic and adult stem cells, is crucial for future clinical applications.
  • Stem cells possess pluripotent plasticity, enabling differentiation into various cell types for treating injuries, organ degeneration, and genetic disorders.

Purpose of the Study:

  • To review future clinical application modalities for stem cell-derived products and therapeutics in liver diseases.
  • To provide a state-of-the-art survey of current knowledge and published work on stem cells for liver disease treatment.

Main Methods:

  • Literature review of current knowledge and published work on stem cell applications in liver diseases.
  • Analysis of biological advantages and disadvantages of different stem cell types.
  • Consideration of ethical aspects and clinically required parameters for human stem cell use.

Main Results:

  • Stem cell therapies hold promise for treating liver diseases by replacing damaged cells or providing therapeutic support.
  • Different stem cell types present unique biological benefits and drawbacks for clinical translation.
  • Successful implementation requires careful consideration of patient risk, stringent indications, long-term outcomes, and cost-benefit analysis.

Conclusions:

  • Reproducible stem cell programmability is key to unlocking diverse clinical applications for liver disease treatment.
  • A comprehensive understanding of stem cell biology, ethics, and clinical parameters is essential for successful therapeutic development.

Related Experiment Videos